B6 mice undergoing a modified DID procedure (2-h 20% ethanol sessions, 5 days per week for 6 weeks) displayed increased anxiety-like behavior compared to water-drinking controls on the EPM and in the L/D box during a battery of tests conducted 1 day (acute) or 21 days (protracted) into abstinence, with effects that were more pronounced during the earlier … Download the Report Individuals of an inbred strain are genetically uniform, also known as isogeneic. Inbred mouse strains exhibit a high degree of uniformity in their inherited characteristics, or phenotypes, which include appearance, behavior, and response to experimental treatments. We currently have up to 16-month-old animals available for sale and will continue holding animals up to 18-months old. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. For the novelty stress, each mouse was transferred from group-housed cages to individual cages. Mice, cells, antibodies (Abs), and reagents C57BL/6 mice from Charles River Laboratories International, Inc. were maintained under specific pathogen-free conditions and used at 8–12 wk of age. The generations are cumulative, so if each of the two separate colonies breed for 10 generations (~2-3 years), they are 20 generations apart, and different substrains with potentially different phenotypes. Mice are available for immediate studies, eliminating your need to wait for animals to naturally age. Data (mean ± SD) are cumulative results (n = 7–8 mice per group) from two independent experiments. These mice are currently produced at our Hollister, CA facility. All animals were housed in appropriate containment facilities at APHA. Search Results for C57bl 6 Mice Charles River Laboratories on Bioz, providing objective ratings for all products used in life science research. Sprague-Dawley and Wistar are the main rat strains. At Charles River, cohorts of male and female mice are set aside at weaning, and will be housed together up until ~77 weeks of age. Which health statuses are available for C57BL/6 mouse colonies. .. Pigment is completely absent from skin, hair and eyes in mice homozygous for Tyr c-2J . Charles River Laboratories female c57bl 6 Female C57bl 6, supplied by Charles River Laboratories, used in various techniques. Developed by C.C. Page: 1; 2; Sort By. Male C57BL/6 (n=42; Charles River Laboratories) and male MRL/MpJ (n=42; The Jackson Laboratory) mice were obtained at 8 weeks of age and housed until 16 weeks of age, which represents the age of peak bone mass ( ). UNIT: K61 All rights reserved. Female BALB/c and C57BL/6 mice were obtained from SPF facilities at Charles River UK Ltd and used at 8 weeks of age. Female C57bl 6, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 92/100, based on 918 PubMed citations. CAT. Please email us at [email protected] to request a health report for this model. LOCATION: Kingston No strain differences were observed in mechanical or thermal hypersensitivity or in edema following the Complete Freund's Adjuvant model of inflammatory pain, indicating specificity in the … C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception Mol Pain. Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached The pyramid mating system ensures our C57BL/6 mice are genetically identical within each mouse strain. 8 Program in Immunology, Memorial Sloan Kettering Cancer Center, New York, New York. treated with Meth A cells ... (Japan Charles River, Tokyo, Japan) were used. Depilated male BALB/c or C57BL/6 mice (Charles River Laboratories) were injected intraperitoneally with DILI-inducing drugs. 4 NCI C57BL/6-cBrd/cBrd/Cr (C57BL/6 albino) 4 NCI C57BL/6NCr 4 NCI FVB/NCr 5 NCI Hybrid Mice | Congenic Mouse 5 NCI B6D2F1/Cr 5 NCI CB6F1/Cr 5 NCI B6-Ly5.1/Cr 6-7 NCI Immunodeficient Models 6 NCI Athymic NCr-nu/nu Mice 6 NCI Athymic NCr-nu/+ Mice 6 NCG Mice 7 NCI NOD.SCID/NCr Mice 7 NCI SCID/NCr Mice (BALB/c background) 7 NCI Cr:NIH-RNU Rats 7 NCI Cr:NIH-RNU/+ Rats 8 Charles River … Let us create one for you. C57BL/6 Substrain Information Little 1921 Jackson Labs 1948 CSAL, France not published Janvier 1993 C57BL/6JRj Harlan 1974 & 1988 Harlan became Envigo in 2015 Harlan became Envigo in 2015 C57BL/6NHsd BRL-RCC 1973 Acquired by Harlan in 2004 C57BL/6JRccHsd Charles River 1974 C57BL/6NCrl ZfV Hannover 1971 Acquired by Taconic in 2002 C57BL/6JTac M&B, Denmark 1988 … Download the Report C57BL/6 Mouse Hematology North American Colonies* January 2008 - December … Data (mean ± SD) are cumulative results (n = 7–8 mice per group) from two independent experiments. As with C57BL/6J, Charles River C57BL/6 (C57BL/NCrl) mice have been used to study a wide array of subjects in biology. Download the Report Major research applications are in immunology, oncology, physiology, pathology, and neuroscience. Search Results for C57bl 6 Charles River Laboratories on Bioz, providing objective ratings for all products used in life science research. Diet and Animals. .. All in vivo experiments were performed using female 8–9 week old mice weighing between 16.8 and 26.3 grams each. ... (Charles River Laboratories). Animals Sixty-seven male C57BL/6 and 32 male DBA/2 mice (3 months old, specific pathogen free) were obtained from Charles River Co. (Gapeung, South Korea) at the beginning of the experiments. Erythrocytes were removed by red blood cell (RBC) lysis buffer, and the remaining cells were cultured in complete DMEM medium (ThermoFisher, cat.no:61965026) supplemented), with 20% of L929 conditioned medium (source of M-CSF) for 7 days. 2–4 month-old adult C57BL/6 (Charles River and Jackson Lab) or LBD-CREB male mice were maintained on a 12 h light/dark cycle with free access to food and water. Many recombinase strains are in the C57BL/6J background, resulting in knockout animals on a mixed strain background. SOPF = VAF ® Elite; they are based on the same monitoring programmes in terms of agents screened, number and age of animals screened, frequency of testing, and recycling policies. Receive the latest news and insights to your inbox. Charles River Laboratories (also its joint venture Vital River in China) is another major supplier of C57BL/6 mice. Seven-week-old male C57Bl/6 mice were purchased from Charles River (Wilmington, Mass), housed two mice per cage under pathogen free conditions, and placed on a 12:12 h light/dark cycle in the research support facility at the University of Kansas Medical Center. The C57BL/6 mice are highly desired because they are used for transgenic/knockout model development. Under isoflurane anesthesia (2–2.5% in a 70% N2 O/30% O2 mixture), mice were placed in a stereotactic apparatus, the skull exposed through a midline incision, cleared of connective tissue and dried. Percent parasitemia was determined on the indicated days. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. This effect was also seen in 3/6 CD1 and 2/6 129SVJ brain regions, but not in the BALB/c strain. C57BL/6J mice present a deletion … How you can use the C57BL/6 Substrain Characterization Panel . To Charles River in 1974 from NIH. Show. Download the Report It was separated from C57BL/6J in 1951. UNIT: K92 To NIH in 1951 from The Jackson Laboratory at F32. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. C57BL 6 Mouse. *This pricing is subject to our General Terms & Conditions of Sale. Article Title: In vivo expansion of regulatory T cells by low-dose interleukin-2 treatment increases allograft survival in corneal transplantation VAF/Plus®, VAF/Elite® (SOPF), and germ-free health statuses are available for these mouse models. Strain code. Inflammation, immunology. As part of a strain’s nomenclatur… You may not know this: every time a new C57BL/6 colony is maintained separately from an existing colony for 20 or more generations, it becomes a new C57BL/6 substrain. The initial stock was a year old in September 2020 and will be 18-months old in March 2021. Where are the C57BL/6-Aged mice produced? Home > Search Results Coat Color: Black Produced: North America, Europe and Japan research models. Breeding location. C57BL/6 mouse models are available globally from Charles River through more than 20 breeding facilities. .. However, breeding with a Cre-recombinase and/or Flp-recombinase mouse is required for the generation of a null allele with the IKMC cassette. Bioz Stars score: 90/100, based on 1 PubMed citations. All mice were given ad libitum access to food and water and … Introducing the C57BL/6 germ-free mouse, the latest addition to the Charles River research animal models portfolio. UNIT: K84 Separate cohorts of mice, at 2 and 18–24 hours post-treatment, were then injected with imaging probes (AMT-750 and AS-680) for imaging 24 hours later to detect biologic changes within damaged tissue. The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, and Harlan Laboratories are the main suppliers. .. In 2005, JAX received C57BL/6N cryopreserved embryos derived from a father-daughter backcross of a 1984 freeze at approximately F126 (now called C57BL/6NJ). C57BL/6 mice, as described earlier [17]. Note: We also offer the C57BL/6-Aged Mouse, the C57BL/6-Germ-Free Mouse (bred in US), the C57BL/6-Elite Mouse with a VAF/Elite® health profile (bred in US), and the C57BL/6-SOPF Mouse with a SOPF health profile (bred in France). C57BL/6J (B6) mice (8 weeks, Charles River Laboratories) were housed in a 12 h light-dark cycle with water and food provided ad libitum. Currently, we are only offering C57BL/6-Aged mice. C57BL/6, female, 22 weeks of age C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse. This unique characteristic makes these mice ideal for creation of novel strains with targeted mutations (gene knockouts). C57Bl/6 and C57Bl/6-FcRn-KO mice were obtained from the Charles River and Jackson laboratories, respectively. This is a very very common mouse, they will send you the right one (probably half of mice at u of Penn researcher will have C57BL/6 background). The mice will be shipped in divided crates with their cagemates. The NIH substrain, C57BL/6N, was later distributed to several institutes including Charles River Laboratories in 1974 (C57BL/6NCrl), to Harlan (now Envigo, C57BL/6NHsd) in … Receive the latest news and insights to your inbox. How will the C57BL/6-Aged mice be shipped. Download the Report. How Well Does the C57BL/6NCrl Mouse Age? UNIT: H47 This is an NIH subline of C57BL/6. Five SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. C57BL/6 mice were i.p. Mice Female or male BALB/c, C57BL/6, SJL, C57BL10.s or C3H mice, 8–10 weeks old, were purchased from Charles River/NCI Laboratories (Wilimington, MA). C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Home > Search Results Download the Report, LOCATION: Hollister Our aged animals are useful for studying various age-related diseases. Number of SNP markers per chromosome in the C57BL/6 Substrain Characterization Panel: Two mice strains were used in this study: (1) wild type C57Bl/6 (Charles River), and (2) transgenic mice in which astrocytes express EGFP under the control of the human GFAP promoter (hGFAPpr-EGFP). The pyramid mating system ensures our C57BL/6 mice are genetically identical within each mouse strain. To Charles River in 1974 from NIH. The International Knockout Mouse Consortium (IKMC) introduces its targeted constructs into C57BL/6N embryonic stem cells. Upon arrival, each dam was weighed and randomly assigned to one of five treatment groups, equalizing the mean starting body weight in each group. 494. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. Physiological Data Summary – C57BL/6J (000664) Hematology Females Males Parameter Units 8 Weeks 16 Weeks 8 Weeks 16 Weeks White blood cell count (WBC) 103 cells/μL 4.9 ± 1.8 5.0 ± 2.0 6.4 ± 2.4 4.5 ± 2.3 Red blood cell count (RBC) 106 cells/μL 8.6 ± 0.7 8.8 ± 0.5 8.2 ± 0.6 8.5 ± 0.5 Hemoglobin g/dL 12.0 ± 1.0 11.9 ± 0.7 11.7 ± 0.8 11.6 ± 1.0 B6(Cg)- Tyr c-2J /J, or B6-albino mice, are C57BL/6J mice that carry a mutation in the tyrosinase gene. Jan-Dec 2019;15:1744806918825046. doi: 10.1177/1744806918825046. Charles River uses our International Genetic Standardization (IGS) program coupled with a pyramid mating system designed to maintain the highest levels of genetic uniformity in our C57BL/6 mice. .. Sorry, you need to enable JavaScript to visit this website. NO. Timed pregnant CD-1 and C57Bl/6 mice were obtained from Charles River Laboratories (Raleigh, NC) on gestational day 0 (GD 0) when they were confirmed sperm positive. Live animals were sent from the NIH to Charles River Laboratories in 1974 (C57BL/6NCrl) and to Harlan Laboratories in 1988 (C57BL/6NHsd). Before the experiment, five mice per cage were maintained in a room with controlled temperature and humidity under a 07:00–19:00 h light cycle with free access to food and water. .. At this point, 6 mice from each strain were sacrificed as pre-fracture controls. Mycobacteria. Download the Report in substrains and sublines of C57BL/6 mice ... the information from Charles River, both barriers are located in the same building without any obvious indication of environmental dif-ferences. C57BL/6 ES cells are used to create transgenic mouse models. Strains 6 and 10 separated about 1937. 7 Research Animal Diagnostic Services, Charles River Laboratories, Wilmington, Massachusetts. All animals were housed in appropriate containment facilities at APHA. At Charles River, cohorts of male and female mice are set aside at weaning, and will be housed together up until ~77 weeks of age. VAF/Elite® (SOPF) mouse models are high-quality, genetically standardized models that are free of select infectious agents and parasites. To Charles River in 2014. C57BL/6 Mouse by Charles River Laboratories Manufacturer Charles River Laboratories Be the first to review this product Developed by C.C. Our Animal Model Evaluation Program allows researchers to assess the quality and compatibility of our mouse models before making a commitment. At that time, a “black subline” (C57BL) and a “brown subline” (C57BR) were established and bred independently. C57BL/6 mice are the most used inbred strain in research. Black. Mice were infected with 10 5 P. yoelii pRBCs. C57BL/6 mice are the most used inbred strain in research. To Charles River in 1974 from NIH. For additional information, including pricing details, please visit the C57BL/6 mouse page on the Charles River Japan website. This strain was developed by injecting a 2.2 kB fragment of the human GFAP promoter fused to the EGFP gene into oocytes of FVB/N mice ( ). Inbred mouse strains exhibit a high degree of uniformity in their inherited characteristics, or phenotypes, which include appearance, behavior, and response to experimental treatments. Strains 6 and 10 separated about 1937. Charles river, taconic, most other mouse suppliers use the n substrain. We also offer the C57BL/6 Mouse, C57BL/6-Germ-Free Mouse, and C57BL/6-Elite (SOPF) Mouse with a VAF/Elite® health profile. C57BL/6 mice from Taconic exhibit reduced parasitemia compared to mice from Charles River. Article Title: Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression .. The specific background strain from which the Ly5.2 gene comes from is unknown. UNIT: R01 Germ-free mice are bred in an axenic environment in order to exclude all microorganisms. C57BL/6 mice are inbred mice developed by C.C. This strain was developed by injecting a 2.2 kB fragment of the human GFAP promoter fused to the EGFP gene into oocytes of FVB/N mice ( ). https://www.selectscience.net › products › c57bl+6-mouse › ?prodID=85057 2–4 month-old adult C57BL/6 (Charles River and Jackson Lab) or LBD-CREB male mice were maintained on a 12 h light/dark cycle with free access to food and water. The ‘-cdf’ suffix after F344 indicates the F344 colony was derived from Charles River Laboratories Fisher 344 rat foundation stock (2011 on). Charles River Laboratories c57bl 6j mice aged 10 C57bl 6j Mice Aged 10, supplied by Charles River Laboratories, used in various techniques. Our interactive eBook includes detailed graphs and reference tables for body composition, chemistry, and hematology on both early and late adult C57BL/6NCrl mice to show how this model changes with age. To NCI via NIAID in 1983. To The Jackson Laboratory in 1948 from Hall. Bioz Stars score: 92/100, based on 167 PubMed citations. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. What is the oldest C57BL/6-Aged mouse you will have available for sale? To Charles River in 2014. We use our International Genetic Standardization (IGS) program coupled with a pyramid mating system designed to maintain the highest levels of genetic uniformity in our C57BL/6 mice. ( b ) After two weeks of acclimatization, a baseline group (n = 6) from each strain was subjected to DEXA scanning and GTT before being sacrificed. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. C57BL/6 and FVB animals appeared most affected, overall (B, C) and with 4/6 regions showing a significant increase (D–I). .. C57BL/6 mice from Taconic exhibit reduced parasitemia compared to mice from Charles River. 000664 ). Bioz Stars score: … Seven-week old male C57BL/6 #027 mice were purchased from Charles River (Wilmington, Mass), C57BL/6J and C57BL/6NJ mice were purchased from Jackson Laboratory’s (Bar Harbor, ME) and maintained in pair housed cages on a 12:12h light/dark cycle in the research support facility at the University of Kansas Medical Center. Scientific & Regulatory Advisory Services, Body Composition Characteristics of Early and Late Adult C57BL/6NCrl Mice, Clinical Chemistry Characteristics of Early and Late Adult C57BL/6NCrl Mice, Hematology Characteristics of Early and Late Adult C57BL/6NCrl Mice. 000664. The pyramid mating system ensures our C57BL/6 mice are genetically identical within each mouse strain. Selecting the appropriate animal model is critical to the success of your research. Learn how our animal model evaluation program can help you determine if the C57BL/6 mouse is right for your research. © 2021 Charles River Laboratories. Developed by C.C. per page . The congenic strain "C57BL/6-Ly5.1" carries the allele of the SJL mouse in the Ptprc gene locus: " Ptprca " or "CD45.1" or “Ly5.1”, which was renamed from “Ly-5.2” in 1987. If you are interested in other aged rat or mouse models, please contact us about our Preconditioning Aging Services. Coat color. In Jackson lab it is called C57BL/6J J=Jax lab. C57BL/6 mouse cells are isolated from C57BL/6 mice purchased from Charles River. C57BL/6 and BALB/c are the main mouse strains. The description of the F344-cdf can be found on the Charles River website. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. UNIT: H44 Two mice strains were used in this study: (1) wild type C57Bl/6 (Charles River), and (2) transgenic mice in which astrocytes express EGFP under the control of the human GFAP promoter (hGFAPpr-EGFP). .. Is the C57BL/6 mouse a good model for the creation of transgenic models? For additional information, including pricing details, please visit the C57BL/6NCrl mouse page on the Vital River Laboratories website. 2003) The onset of the phenotype appears to be between 2 and 6 weeks of age (Pritchett-Corning, 2012). ZERO BIAS - scores, … Download the Report, LOCATION: Raleigh UNIT: R02 Can't find the model you need? Scientific & Regulatory Advisory Services, C57BL/6 mouse page on the Charles River Japan website, C57BL/6NCrl mouse page on the Vital River Laboratories website, The Role of the C57BL/6N Mouse in the Creation of Future Genetically Engineered Models White Paper, Reducing Aggression in Mice Technical Sheet, Phenotype and genotype comparison for C57BL/6N substrains contributing to the International Mouse Phenotyping Consortium (IMPC), Biochemistry and Hematology for C57BL/6NCrl Mouse Colonies in North America for January 2008 – December 2012, Weight of Male C57BL/6NCrl Mice Fed High Fat Diet D12492, Fasting Blood Glucose Levels in Male C57BL/6NCrl Mice Fed High Fat Diet D12492, Nutrition Information for Enhancing or Expressing a Desired Disease Condition. Have its genome sequenced background, resulting in knockout animals on a mixed strain background, safety and efficacy,. 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All autosomes and the first to have its genome sequenced strain from which the Ly5.2 comes. Have the deletion in the C57BL/6J background, resulting in knockout animals on a mixed strain.. Mouse strain 5 P. yoelii pRBCs density, and immunology = 7–8 mice per group ) two. Mouse colonies are genetically uniform, also known as isogeneic to NIH 1951! September 2020 and will continue holding animals up to 16-month-old animals available for immediate,...